A 23-year-old woman presented with diffuse white hair nodules, hair fr
agility, and the inability to grow long hair. Examination of specimens
under the light microscope showed the morphologic characteristics of
trichorrhexis nodosa. Results of tests revealed hypothyroidism. Treatm
ent with a daily dose of 0.1 mg L-thyroxine sodium for six months rest
ored euthyroidism and concurrently normalization of the hair defect wa
s observed. The corrected hair defect observed after replacement thera
py may point toward a causal relationship between hypothyroidism and t
richorrhexis nodosa. To the best of our knowledge, this is the first r
eport of trichorrhexis nodosa associated with hypothyroidism.