CHRONIC PROLIFERATIVE DERMATITIS IN MICE - NEUTROPHIL-ENDOTHELIUM INTERACTIONS AND THE ROLE OF ADHESION MOLECULES

The murine chronic proliferative dermatitis mutation (cpdm/cpdm) is ch aracterized by epidermal hyperplasia and hyperproliferation of ventral and dorsal skin sites. The expression of endothelium-associated adhes ion molecules was studied in combination with the binding capacity of various cell types on frozen sections of the affected skin. In correla tion with the relative absence of lymphocytes in the cpdm/cpdm skin no lymphocyte binding could be observed, but avid adhesion of neutrophil s was seen. Binding of neutrophils could be blocked with antibodies ag ainst L-selectin, LFA-I, CR3 and anti ICAM-1. No expression of vascula r addressins or E-selectin on endothelium in the dermis was found. The cpdm/cpdm mutation has therefore characteristics of a psoriasis-like as well as a more generalized inflammatory skin condition.