PARAGANGLIOMA OF THE URINARY-BLADDER

A paraganglioma of the urinary bladder in a 60-year-old woman presente d with irritative voiding symptoms, without hematuria or hypertension. Sonography revealed a well-limited ovoid mass of the posterior wall, and cystoscopy showed that it was covered by normally appearing mucosa , Treatment consisted of transurethral resection. and the patient has been followed for 2 years without recurrence. Histologically the lesio n consisted of small nests of spindle cells with clear to acidophilic cytoplasm: mitotic activity was inconspicuous, Immunohistochemical ana lyses revealed that the tumor cells were strongly positive for neuron- specific enolase and chromogranin A, and negative for cytokeratin, vim entin, neurofilaments, glial fibrillary acid protein and HMB 35. Suste ntacular cells at the periphery of neoplastic cell clusters were posit ive for S-100 protein.