PARTICIPATION OF OXYGEN-FREE RADICALS IN THE OXIDE-REDUCTION OF PROTEINS

Recent studies have focused attention on the possible role of active o xygen species on protein damage and degradation. The reactions of free radicals on biomolecules are important in physiology and pathology, A number of systems that generate free radicals catalyze the oxidative modification of proteins in two species: protein peroxides, which can consume important antioxidants; and protein-bound reducing moieties, w hich can reduce transition metals, and may enhance their activity in r adical reactions. Protein oxidation also contributes to the pool of da maged enzymes and accumulation of abnormal and damaged proteins, which increases during aging and in various pathological states, such as at herosclerosis, cancer, etc.