USE OF THE SYRIAN-HAMSTER EMBRYO (SHE) CELL-TRANSFORMATION ASSAY FOR THE INVITRO TESTING OF 5 PESTICIDES

Authors
DUSINSKA M SLAMENOVA D KOLMAN A
Citation
M. Dusinska et al., USE OF THE SYRIAN-HAMSTER EMBRYO (SHE) CELL-TRANSFORMATION ASSAY FOR THE INVITRO TESTING OF 5 PESTICIDES, ATLA. Alternatives to laboratory animals, 21(2), 1993, pp. 202-205
Citations number
23
Categorie Soggetti
Veterinary Sciences
Journal title
ATLA. Alternatives to laboratory animals → ACNP
ISSN journal
02611929
Volume
21
Issue
2
Year of publication
1993
Pages
202 - 205
Database
ISI
SICI code
0261-1929(1993)21:2<202:UOTSE(>2.0.ZU;2-Y
Abstract
The morphological transformation of Syrian hamster embryo (SHE) cells has been used for the in vitro testing of the transforming activity of five pesticides (Dual, Vucht 524, Piritione, Decemtione and Supercype rmethrin). Morphological transformation with two known inducers, 3-met hylcholanthrene and N-methyl-N'-nitro-N-nitrosoguanidine, was used as a positive control. It was found that only one of the tested pesticide s, Dual, failed to induce morphological transformation in SHE cells, w hereas the remaining four demonstrated varying degrees of positive res ponse and could be regarded as potential carcinogenic chemicals.