J. Kawiak et al., POPULATIONS OF THYMOCYTES AND PERIPHERAL-BLOOD LEUKOCYTES IN LEUKEMIA-BEARING MICE TREATED WITH G-CSF, Immunology and cell biology, 74(2), 1996, pp. 163-166
The influence of granulocyle-colony stimulating factor (G-CSF) on thym
ocyte subsets and peripheral blood leucocytes in leukaemia L1210-beari
ng mice was evaluated. Leukaemia-bearing mice have a markedly reduced
L3T4(+)Lyt2(+) thymocyte subpopulation. We observed 'correction' of re
lative values of thymocyte subpopulations induced by treatment of mice
with a G-CSF preparation. The suggestion is presented that this could
result from liberation of lymphocyte T precursor cells from the bone
marrow and increased homing of them into the thymus. The direct or ind
irect influence of G-CSF on the L3T4(+)Lyt2(+) subpopulation of thymoc
ytes is discussed.