J. Brennum et al., SUMATRIPTAN HAS NO CLINICALLY RELEVANT EFFECT IN THE TREATMENT OF EPISODIC TENSION-TYPE HEADACHE, European journal of neurology, 3(1), 1996, pp. 23-28
In a randomized, multi-centre, double-blind, placebo-controlled, paral
lel group study, the efficacy of 100 mg oral sumatriptan was compared
with that of placebo in the treatment of episodic tension-type headach
e. The patients were recruited from the general population in the vici
nity of the study centres, by randomly mailed invitations. One or more
attacks were treated with sumatriptan by 54 patients and with placebo
by 57 patients. A seven-point verbal rating scale was used for hourly
assessments of headache relief, 1-4 h after treatment. According to t
he predefined primary end-point of the study, which was moderate or co
mplete relief of headache 2 and 4 h after treatment of the first attac
k, there was no significant difference between sumatriptan and placebo
treatment. Sumatriptan did perform statistically significantly better
than placebo at some time points, but the effect was not considered c
linically relevant. We conclude that sumatriptan should not be used in
treatment of tension-type headache. The marked difference in effect o
f sumatriptan in treatment of migraine and tension-type headache argue
s against the idea that migraine and tension-type headache are part of
a continuum of headache disorders.