INTERLEUKIN-1-BETA SPECIFICALLY STIMULATES NITRIC-OXIDE PRODUCTION INTHE HYPOTHALAMUS

Authors
BRUNETTI L VOLPE AR RAGAZZONI E PREZIOSI P VACCA M
Citation
L. Brunetti et al., INTERLEUKIN-1-BETA SPECIFICALLY STIMULATES NITRIC-OXIDE PRODUCTION INTHE HYPOTHALAMUS, Life sciences, 58(25), 1996, pp. 373-377
Citations number
19
Categorie Soggetti
Biology,"Medicine, Research & Experimental","Pharmacology & Pharmacy
Journal title
Life sciences → ACNP
ISSN journal
00243205
Volume
58
Issue
25
Year of publication
1996
Pages
373 - 377
Database
ISI
SICI code
0024-3205(1996)58:25<373:ISSNPI>2.0.ZU;2-B
Abstract
In previous experiments we have shown the role of nitric oxide (NO) in basal and interleukin-1 beta (IL-1 beta)-induced CRH and ACTH release in vitro. Now, we have studied the possible production of NO from hyp othalamic cell cultures, particularly after IL-1 beta stimulation or L -NOArg inhibition, by high performance liquid chromatographic (HPLC) a ssay of L-citrulline production, adding further evidence for a role of NO in IL-1 beta activity in the hypothalamus.