T. Mcmorrow et al., STRUCTURAL ORGANIZATION AND SEQUENCE-ANALYSIS OF THE GLOBIN LOCUS IN ATLANTIC SALMON, DNA and cell biology, 15(5), 1996, pp. 407-414
Preliminary analysis of Atlantic salmon alpha- and beta-globin genes i
ndicated that these genes are linked in a 3' to 3' orientation, with t
he RNA-coding sequences located on opposite strands, In this report, w
e show that two different alpha-globin genes have the same orientation
and are encoded on the same strand whereas two different beta-globin
genes are encoded on the opposite strand and also have the same orient
ation, This cluster of globin genes is divided into two subclusters: o
ne for the Bohr globin genes and one for the non-Bohr globin genes, Th
is is the first evidence for this type of arrangement found for globin
genes, DNase I footprint analysis of two of the globin promoters show
erythroid-specific transcription factor binding sites that have also
been found in human and other mammalian globin genes.