Though MD-PhD programs have grown rapidly since their introduction in
the mid-1960s, and are widely regarded as fostering excellent young in
vestigators and future leaders in research and academic medicine, the
types of research careers their, graduates can be expected to pursue h
ave been a point of some confusion. Some regard MD-PhD programs as a f
lexible approach to scientific training, producing both basic scientis
ts and clinical investigators, while others tend to view these program
s as generating either one type of researcher or the other. This range
of expectations associated with dual-degree programs and their gradua
tes has perplexed observers over the years and complicated the efforts
of planners and policymakers in projecting workforce needs and genera
ting recommendations for research training. To learn more about the re
search careers of MD-PhDs and how these investigators fit into the lar
ger biomedical research workforce, the authors undertook a review of t
he types of research proposed by dual-degree and other investigators i
n 12,116 applications to the National Institutes of Health in 1993 and
1994. In comparing the types of research projects proposed by investi
gators of various degree types (MDs, MD-PhDs, and PhDs) the authors fo
und that the research interests of the MD-PhDs studied were more close
ly aligned with the laboratory pursuits of most of their PhD counterpa
rts than with the more clinically-oriented endeavors of thee with the
MD degree alone. During a time when there are persistent concerns abou
t a shortage of investigators to conduct clinical research and growing
fears that America's universities may De producing more PhDs than can
be meaningfully emloyed in the scientific enterprise, the authors' fi
nding indicates a need for future workforce planning to better reflect
the respective roles Flayed by MDs, MD-PhDs, and PhDs in biomedical a
nd behavioral research.