CONFIRMATION OF A DOPAMINE METABOLITE IN PARKINSONIAN BRAIN-TISSUE BYGAS-CHROMATOGRAPHY MASS-SPECTROMETRY

Authors
MATTAMMAL MB CHUNG HD STRONG R HSU FF
Citation
Mb. Mattammal et al., CONFIRMATION OF A DOPAMINE METABOLITE IN PARKINSONIAN BRAIN-TISSUE BYGAS-CHROMATOGRAPHY MASS-SPECTROMETRY, Journal of chromatography. Biomedical applications, 614(2), 1993, pp. 205-212
Citations number
31
Categorie Soggetti
Chemistry Analytical
Journal title
Journal of chromatography. Biomedical applications → ACNP
ISSN journal
03784347
Volume
614
Issue
2
Year of publication
1993
Pages
205 - 212
Database
ISI
SICI code
0378-4347(1993)614:2<205:COADMI>2.0.ZU;2-K
Abstract
Gas chromatography mass spectrometry was used to identify a dopamine m etabolite isolated from the substantia nigra of parkinsonian brain tis sue. Incubation of dopamine with monoamine oxidase B gave the same pro duct which was identified as 3,4-dihydroxyphenylacetaldehyde. The stru cture of the compound was established by chemical synthesis, metastabl e ion measurement and high-resolution mass spectrometry.