Sd. Deterawadleigh et al., AFFECTED-SIB-PAIR ANALYSES REVEAL SUPPORT OF PRIOR EVIDENCE FOR A SUSCEPTIBILITY LOCUS FOR BIPOLAR DISORDER, ON 21Q, American journal of human genetics, 58(6), 1996, pp. 1279-1285
In 22 multiplex pedigrees screened for linkage to bipolar disorder, by
use of 18 markers on chromosome 21q, single-locus affected-sib-pair (
ASP) analysis detected a high proportion (57%-62%) of alleles shared i
dentical by descent (IBD), with P values of .049-.0008 on nine marker
loci. Multilocus ASP analyses revealed locus trios in the distal regio
n between D21S270 and D21S171, with excess allele sharing (nominal P v
alues <.01) under two affection-status models, ASM I (bipolars and sch
izoaffectives) and ASM II (ASM I plus recurrent unipolars). In additio
n, under ASM I, the proximal interval spanned by D21S1436 and D21S65 s
howed locus trios with excess allele sharing (nominal P values of .03-
.0003). These findings support prior evidence that a susceptibility lo
cus for bipolar disorder is on 21q.