A CLASS OF HIGHLY POLYMORPHIC TETRANUCLEOTIDE REPEATS FOR CANINE GENETIC-MAPPING

Authors
FRANCISCO LV LANGSTON AA MELLERSH CS NEAL CL OSTRANDER EA
Citation
Lv. Francisco et al., A CLASS OF HIGHLY POLYMORPHIC TETRANUCLEOTIDE REPEATS FOR CANINE GENETIC-MAPPING, Mammalian genome, 7(5), 1996, pp. 359-362
Citations number
23
Categorie Soggetti
Biology,"Genetics & Heredity","Biothechnology & Applied Migrobiology
Journal title
Mammalian genome → ACNP
ISSN journal
09388990
Volume
7
Issue
5
Year of publication
1996
Pages
359 - 362
Database
ISI
SICI code
0938-8990(1996)7:5<359:ACOHPT>2.0.ZU;2-D
Abstract
We have identified and characterized a new class of polymorphic marker s for the canine genome from a simple tetranucleotide repeat sequence, (GAAA)(n). Genetic markers derived from this repeat are highly polymo rphic compared with other canine microsatellites, yet are stable enoug h to be useful for following Mendelian inheritance in multigeneration pedigrees. We show further that (GAAA)(n) repeats are distributed thro ughout the canine genome and occur with sufficient frequency to be use ful in the development of a framework map of the canine genome.