PRICE - A DOWNSTREAM TARGET FOR CERAMIDE-INDUCED APOPTOSIS AND FOR THE INHIBITORY-ACTION BCL-2

Authors
SMYTH MJ PERRY DK ZHANG JD POIRIER GG HANNUN YA OBEID LM
Citation
Mj. Smyth et al., PRICE - A DOWNSTREAM TARGET FOR CERAMIDE-INDUCED APOPTOSIS AND FOR THE INHIBITORY-ACTION BCL-2, Biochemical journal, 316, 1996, pp. 25-28
Citations number
23
Categorie Soggetti
Biology
Journal title
Biochemical journal → ACNP
ISSN journal
02646021
Volume
316
Year of publication
1996
Part
1
Pages
25 - 28
Database
ISI
SICI code
0264-6021(1996)316:<25:P-ADTF>2.0.ZU;2-2
Abstract
The novel lipid second messenger, ceramide, specifically induced poly( ADP-ribose) polymerase cleavage through activation of the protease prI CE. Over-expression of Bcl-2 inhibited ceramide-induced poly(ADP-ribos e) polymerase proteolysis and protected cells from ceramide-induced de ath. These data provide the first insight into the mechanism by which ceramide mediates apoptosis and suggest a mechanism by which Bcl-2 pro tects from cell death.