THYMULIN REDUCES HYPERALGESIA INDUCED BY PERIPHERAL ENDOTOXIN INJECTION IN RATS AND MICE

In a new model of peripheral localized inflammation, induced by intrap lantar endotoxin (1.25 mu g) injection in the hind paw of rats and mic e, thymulin, a hormone of the thymus gland involved in immunomodulatio n, reduced inflammatory pain. High doses of thymulin reduced significa ntly, and in a dose-dependent manner, mechanical hyperalgesia as asses sed by the paw pressure test and thermal hyperalgesia as assessed by t he hot plate test and tail immersion test.