Between 1975 and 1994, 52 hemispherectomies, of which two were anatomi
cal and 50 hemidecortications, were performed at Johns Hopkins Medical
Institutions. Eighteen patients were 2 years old or less. There were
three perioperative mortalities and one patient died 9 months later fr
om causes not related to surgery. One patient developed hydrocephalus
6 years postsurgery and has been treated effectively. Seizure control
and the functional status of each patient were measured as outcome var
iables. Forty-six (96%) of the surviving patients were seizure free or
had reduced seizures as of their last follow-up examination. Twenty-o
ne individuals (44%) were participating in age-appropriate classes or
working independently, 18 were classified as semiindependent, and nine
children will likely depend on a lifetime of assisted living. The rel
ationships between the outcome variables and the patient's age at surg
ery, the interval to surgery, and the etiology of the disease were com
pared. The authors' clinical experiences strongly suggest the importan
ce of a multidisciplinary approach to patient selection and follow-up
care. Moreover, anesthetic management of infant surgery is a major com
ponent of success.