EXPRESSION AND SIGNAL-TRANSDUCTION OF THE FLT3 TYROSINE KINASE RECEPTOR

Authors
ROSNET O BUHRING HJ DELAPEYRIERE O BESLU N LAVAGNA C MARCHETTO S RAPPOLD I DREXLER HG BIRG F ROTTAPEL R HANNUM C DUBREUIL P BIRNBAUM D
Citation
O. Rosnet et al., EXPRESSION AND SIGNAL-TRANSDUCTION OF THE FLT3 TYROSINE KINASE RECEPTOR, Acta haematologica, 95(3-4), 1996, pp. 218-223
Citations number
29
Categorie Soggetti
Hematology
Journal title
Acta haematologica → ACNP
ISSN journal
00015792
Volume
95
Issue
3-4
Year of publication
1996
Pages
218 - 223
Database
ISI
SICI code
0001-5792(1996)95:3-4<218:EASOTF>2.0.ZU;2-M
Abstract
FLT3 is a receptor tyrosine kinase of 130-155 kDa expresssed on normal bone marrow stem and early progenitor cells and on leukemic blasts fr om patients with acute leukemias. The FLT3 ligand, FL, is a new cytoki ne which acts on hematopoietic progenitors in synergy with other cytok ines. FLT3 transduces FL-mediated signal through interaction with a nu mber of cytoplasmic substrates.