A. Jazayeri et al., UMBILICAL PLASMA ERYTHROPOIETIN CORRELATIONS WITH BLOOD-GASES AND GESTATIONAL-AGE IN APPROPRIATELY GROWN INFANTS, American journal of perinatology, 13(4), 1996, pp. 227-230
Erythropoietin (EPO) levels were measured using an ELISA method in umb
ilical cord plasma from 68 appropriately grown neonates at 27 to 43 we
eks of gestation (EGA). A consistent but small (5%) difference was fou
nd between the EPO levels in the umbilical artery (Ua), 21.0 +/- 2.5 m
lU/mL (mean +/- SEM), and umbilical vein (Uv), 22.0 +/- 2.7 mlU/mL (p<
0.02, n=30). Significant inverse correlations were found between Ua EP
O levels and pO(2) (r=-0.44, p<0.002), pH (r=-0.68, p<0.0001), as well
as base deficit (r=-0.56, p<0.0001). A significant correlation was fo
und between ECA and Ua EPO from 27 to 43 weeks of gestation (r=0.45, p
<0.001, n= 68). One and 5 minute Apgar scores did not correlate with E
PO. These findings indicate that EPO correlates strongly with cord gas
parameters and thus ma): serve as a clinically useful marker for both
subacute fetal distress and chronic uteroplacental insufficiency.