STUDIES ON THE SYNTHESIS OF 16-ALPHA-[F-18]FLUOROESTRADIOL

Authors
ROMER J STEINBACH J KASCH H
Citation
J. Romer et al., STUDIES ON THE SYNTHESIS OF 16-ALPHA-[F-18]FLUOROESTRADIOL, Applied radiation and isotopes, 47(4), 1996, pp. 395-399
Citations number
8
Categorie Soggetti
Nuclear Sciences & Tecnology","Radiology,Nuclear Medicine & Medical Imaging","Chemistry Inorganic & Nuclear
Journal title
Applied radiation and isotopes
ISSN journal
09698043 → ACNP
Volume
47
Issue
4
Year of publication
1996
Pages
395 - 399
Database
ISI
SICI code
0969-8043(1996)47:4<395:SOTSO1>2.0.ZU;2-K
Abstract
For preparing 16 alpha-[F-18]fluoroestradiol, a new one-pot procedure reported in the literature was elaborated in detail. The experimental conditions for synthesizing the required precursor and for converting it into 16 alpha-fluoroestradiol or 16 alpha-[F-18]fluoroestradiol are given. The synthesis consists of the fluoridation reaction and hydrol ysis reactions. For rapid hydrolysis of the fluorosteroid formed in th e fluoridation reaction two methods are presented. The synthesis time does not exceed 1 h. Pure 16 alpha-[F-18]fluoroestradiol can be obtain ed in a 70% overall radiochemical yield.