POLYMORPHISM AND PSEUDOPOLYMORPHISM OF THE ANTIBACTERIAL NITROFURANTOIN

Authors
CAIRA MR PIENAAR EW LOTTER AP
Citation
Mr. Caira et al., POLYMORPHISM AND PSEUDOPOLYMORPHISM OF THE ANTIBACTERIAL NITROFURANTOIN, Molecular crystals and liquid crystals science and technology. Section A, Molecular crystals and liquid crystals, 278, 1996, pp. 241-264
Citations number
33
Journal title
Molecular crystals and liquid crystals science and technology. Section A, Molecular crystals and liquid crystals → ACNP
ISSN journal
1058725X
Volume
278
Year of publication
1996
Pages
241 - 264
Database
ISI
SICI code
1058-725X(1996)278:<241:PAPOTA>2.0.ZU;2-E
Abstract
A physicochemical study of six crystalline modifications of the drug n itrofurantoin Is presented. These forms comprise two polymorphs, two m onohydrates, a DMF solvate and a DMSO solvate. The clathrate nature of the solvates as well as their thermal decompositions are described. T he results of dissolution rate measurements for the polymorphs and mon ohydrates are discussed in relation to the formulation of the drug.