In this paper, we examine the performance of a pencil-and-paper screen
ing questionnaire on depressive symptoms (the Center for Epidemiologic
Studies Depression Scale, or CES-D) in a sample of 120 adult American
Indians belonging to a single Northwest Coast tribe. Results of facto
r analyses suggest that somatic complaints and emotional distress are
not well differentiated from each other in this population. CES-D scor
es (which have shown good sensitivity and specifity for depressive dis
orders in this sample) also show weak and apparently nonsignificant tr
ends to be elevated in the presence of other psychiatric diagnoses (in
cluding alcoholism) or general impairment. However, because of the use
of a convenience sample (rather than a probability sample), analyses
of associations between study factors - including comorbidity - are li
able to produce spurious results due to selection bias (including Berk
son bias). On this basis, we suggest that the use of probability sampl
es should assume a high priority in cross-cultural studies. The study
of the entire population of interest is another solution to the sampli
ng problem, particularly in small communities.