GANGLION CELL-CONTAINING TUMORS OF THE PITUITARY-GLAND

The ganglion cell-containing tumors of the pituitary are rare lesions of undetermined histogenesis and nosology. A review of the literature revealed 42 such tumors, including the 3 cases described below. On the basis of this review, the tumors were divided into two histologic gro ups, one consisting of both adenomatous and gangliocytic elements (32 cases), and the other of the gangliocytic component only (10 cases). T he first group of tumors were more common in females (23 of 32 cases) and were often active endocrinologically (28 of 32 cases), and acromeg aly was the most common manifestation (19 cases). The second group was also more common in females (7 of 10 cases) but was less frequently a ctive endocrinologically (3 of 10 cases). We review histologic and imm unocytochemical findings in these tumors and discuss their histogenesi s. We propose that the term mixed pituitary adenoma-ganglio-cytoma be used for the first group and gangliocytoma for the second. The two gro ups should be kept separate until their histogenesis is better underst ood.