EXPRESSION OF P53 IN CONJUNCTIVAL MELANOCYTIC NEVI - AN IMMUNOHISTOCHEMICAL STUDY

Authors
JAY V HO M HUNTER W ROOTMAN D ZIELENSKA M
Citation
V. Jay et al., EXPRESSION OF P53 IN CONJUNCTIVAL MELANOCYTIC NEVI - AN IMMUNOHISTOCHEMICAL STUDY, Archives of pathology and laboratory medicine, 120(4), 1996, pp. 378-379
Citations number
5
Categorie Soggetti
Pathology,"Medical Laboratory Technology","Medicine, Research & Experimental
Journal title
Archives of pathology and laboratory medicine
ISSN journal
00039985 → ACNP
Volume
120
Issue
4
Year of publication
1996
Pages
378 - 379
Database
ISI
SICI code
0003-9985(1996)120:4<378:EOPICM>2.0.ZU;2-7
Abstract
The objective of this study was to evaluate conjunctival nevi for p53 gene mutations. We studied 11 conjunctival nevi by immunohistochemistr y with the DO7 monoclonal p53 antibody as well as the cell proliferati on marker, MIB1. Of the 11 cases, 2 were negative, 2 had less than 1%, and 7 had more than 2% p53 immunopositive nuclei with no direct corre lation with MIB1 positivity. Our results suggest altered expression of p53 in conjunctival nevi.