TRANSFORMING GROWTH-FACTOR-BETA FAILS TO INHIBIT ALLOGRAFT-REJECTION OR VIRUS-INDUCED AUTOIMMUNE DIABETES IN TRANSGENIC MICE

Authors
LEE MS SAWYER S ARNUSH M KRAHL T VONHERRATH M OLDSTONE MBA SARVETNICK N
Citation
Ms. Lee et al., TRANSFORMING GROWTH-FACTOR-BETA FAILS TO INHIBIT ALLOGRAFT-REJECTION OR VIRUS-INDUCED AUTOIMMUNE DIABETES IN TRANSGENIC MICE, Transplantation, 61(7), 1996, pp. 1112-1113
Citations number
10
Categorie Soggetti
Immunology,Surgery,Transplantation
Journal title
Transplantation → ACNP
ISSN journal
00411337
Volume
61
Issue
7
Year of publication
1996
Pages
1112 - 1113
Database
ISI
SICI code
0041-1337(1996)61:7<1112:TGFTIA>2.0.ZU;2-1
Abstract
Transgenic mice whose pancreata express transforming growth factor-bet a (TGF-beta) directed by an insulin promoter (Ins-TGF-beta mice) were used to assess the effect of local TGF-beta 1 on allograft rejection a nd on autoimmune diabetes occurring as a cross-reaction to viral antig ens. Pancreatic TGF-beta 1 did not delay allograft rejection, nor did it inhibit autoimmune diabetes after lymphocytic choriomeningitis infe ction of double transgenic mice (LCMV/TGF-beta 1 mice). These results suggest that local TGF-beta 1 does not serve as an immunosuppressive a gent for allograft rejection or virus-mediated autoimmune diabetes.