STEROIDS AND RELATED STUDIES .90. CERTAIN NEW AZASTEROIDAL BISQUATERNARY NEUROMUSCULAR BLOCKERS

Authors
ABRAHAM J JINDAL DP SINGH H PATNAIK GK SRIMAL RC
Citation
J. Abraham et al., STEROIDS AND RELATED STUDIES .90. CERTAIN NEW AZASTEROIDAL BISQUATERNARY NEUROMUSCULAR BLOCKERS, European journal of medicinal chemistry, 28(3), 1993, pp. 231-234
Citations number
16
Categorie Soggetti
Chemistry Medicinal
Journal title
European journal of medicinal chemistry → ACNP
ISSN journal
02235234
Volume
28
Issue
3
Year of publication
1993
Pages
231 - 234
Database
ISI
SICI code
0223-5234(1993)28:3<231:SARS.C>2.0.ZU;2-Z
Abstract
Bisquaternary azasteroids HS-1177 7 and HS-1181 8, structurally resemb ling chandonium 2 in rings A and B characteristics, and HS-1184 6, in part resembling HS-467 1 have been prepared and characterised. All 3 c ompounds, each possessing 16alpha-methyltrimethylammonium functions, w ere prepared as potential neuromuscular blocking agents. They were fou nd to be active but less effective than chandonium.