UTILITY OF OYLTETRAHYDROFURAN-2'-YL)-3-BENZYLOXYMETHYLTHYMINE FOR THESYNTHESIS OF 5'-MODIFIED FURANOID NUCLEOSIDE ANALOGS

Authors
TENG K BHARADWAJ R COOK PD
Citation
K. Teng et al., UTILITY OF OYLTETRAHYDROFURAN-2'-YL)-3-BENZYLOXYMETHYLTHYMINE FOR THESYNTHESIS OF 5'-MODIFIED FURANOID NUCLEOSIDE ANALOGS, Synlett, (4), 1996, pp. 346-348
Citations number
7
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synlett → ACNP
ISSN journal
09365214
Issue
4
Year of publication
1996
Pages
346 - 348
Database
ISI
SICI code
0936-5214(1996):4<346:UOOFT>2.0.ZU;2-7
Abstract
A series of 5'-modified furanoid nucleosides have been prepared in ver y good yields by the reaction of oxytetrahydrofuran-2'-yl)-3-benzyloxy methylthymine (1) with alcohols, a sulfide, and TMS-azide in the prese nce of TMSOTf. The reactions proceed in a stereospecific manner to pro vide only beta-glycosylation products.