FIRST SYNTHESIS OF THE METHYL SYN 3-CF3-ISOSERINATE

Authors
ABOUABDELLAH A BEGUE JP BONNETDELPON D
Citation
A. Abouabdellah et al., FIRST SYNTHESIS OF THE METHYL SYN 3-CF3-ISOSERINATE, Synlett, (4), 1996, pp. 399-400
Citations number
23
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synlett → ACNP
ISSN journal
09365214
Issue
4
Year of publication
1996
Pages
399 - 400
Database
ISI
SICI code
0936-5214(1996):4<399:FSOTMS>2.0.ZU;2-N
Abstract
A [2+2] cycloaddition of the trifluoromethyl aldimine 5 with a ketene provided stereoselectively the CF3-substituted. beta-lactam 4 in a 50 % yield. Further steps of ring opening and deprotections led to the me thyl syn-3-CF3-isoserinate which is a new fluoro analogue of the C-13 side-chain of taxoids.