SYNTHESIS OF MACROCYCLIC ENEDIYNES BY TWOFOLD C-ALKYLATION

Authors
KONIG B PITSCH W DIX I JONES PG
Citation
B. Konig et al., SYNTHESIS OF MACROCYCLIC ENEDIYNES BY TWOFOLD C-ALKYLATION, Synthesis, (4), 1996, pp. 446-448
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthesis → ACNP
ISSN journal
00397881
Issue
4
Year of publication
1996
Pages
446 - 448
Database
ISI
SICI code
0039-7881(1996):4<446:SOMEBT>2.0.ZU;2-8
Abstract
The alkylation of malonate derivatives with the new bis-electrophile 4 gave 18-membered macrocyclic enediynes 6a-c by a 2:2 alkylation proce ss. The thermal stability of the bis(enediyne) 6a was investigated by differential scanning calorimetry. X-ray structure analyses revealed c hair and twisted conformations of the macrocycles 6b and 6c in the cry stal.