ELEVATED LEVELS OF THE CHROMOSOMAL PROTEIN HMG-17 IN CHRONIC MYELOGENIC LEUKEMIA

The High Mobility Group protein HMG 17 has been isolated from human le ukemia cells obtained from patients with chronic myelogenic leukemia ( CML). The level of expression of HMG 17 was investigated. Human leukem ia cells have three times more HMG 17 than normal human leukocytes. Th ree other malignant tissues were also compared. Two of these -breast a denocarcinoma and intestine- also exhibit higher amounts of HMG 17. Th e elevated expression of HMG 17 suggests that the level of the protein may be associated with rates of cellular proliferation.