Rc. Srivastava et al., REDUCTION OF CISPLATINUM-INDUCED NEPHROTOXICITY BY ZINC HISTIDINE COMPLEX - THE POSSIBLE IMPLICATION OF NITRIC-OXIDE, Biochemistry and molecular biology international, 36(4), 1995, pp. 855-862
Cisplatin is a prominent member of the effective broad spectrum antitu
mor drugs. The clinical usage of cisplatin is, however, restricted due
to some adverse side effects including renal toxicity. The present st
udy demonstrates the protective effect of a Zinc-chelate of histidine,
[Zn-Hist], against cisplatin induced nephrotoxicity and gastrointesti
nal toxicity as shown by decreases in BUN, creatinine and lower incide
nce of diarrhoea. The observed inhibition in cisplatin induced renal a
nd hepatic lipid peroxidation by [Zn-Hist] pretreatment, suggests an i
mportance for Zn in stabilisation of membrane integrity probably throu
gh the displacement of the redox-active metals that may;be responsible
for inducing peroxidative damage at target sites. The findings also s
uggest that cisplatin may play biochemical role in arginine-metabolism
including nitric oxide (NO) production.