TEMPERATURE AND PROTEINS - LITTLE THINGS CAN MEAN A LOT

Authors
SOMERO GN
Citation
Gn. Somero, TEMPERATURE AND PROTEINS - LITTLE THINGS CAN MEAN A LOT, News in physiological sciences, 11, 1996, pp. 72-77
Citations number
13
Categorie Soggetti
Physiology
Journal title
News in physiological sciences → ACNP
ISSN journal
08861714
Volume
11
Year of publication
1996
Pages
72 - 77
Database
ISI
SICI code
0886-1714(1996)11:<72:TAP-LT>2.0.ZU;2-L
Abstract
protein structures are highly sensitive to temperature because their n et free energies of stabilization are low, about equal to energies ass ociated with formation of a few noncovalent (''weak'') bonds. Temperat ure-adaptive changes in protein stability and function may result from minor changes in amino acid sequence at regions outside active sites and from accumulation of stabilizing solutes in the cell.