MOLECULAR-BASIS FOR FUNCTIONAL DIFFERENCES OF AMPA-SUBTYPE GLUTAMATE RECEPTORS

Authors
OZAWA S ROSSIER J
Citation
S. Ozawa et J. Rossier, MOLECULAR-BASIS FOR FUNCTIONAL DIFFERENCES OF AMPA-SUBTYPE GLUTAMATE RECEPTORS, News in physiological sciences, 11, 1996, pp. 77-82
Citations number
15
Categorie Soggetti
Physiology
Journal title
News in physiological sciences → ACNP
ISSN journal
08861714
Volume
11
Year of publication
1996
Pages
77 - 82
Database
ISI
SICI code
0886-1714(1996)11:<77:MFFDOA>2.0.ZU;2-U
Abstract
To trace the molecular basis of functional properties of native pha-am ino-3-hyduoxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors, we have coupled patch-clamp recordings and reverse transcription followe d by polymerase chain reaction amplification. AMPA receptors lacking t he GluR2 subunit in a population of hippocampal neurons exhibited a st rong inward rectification and were highly permeable to Ca2+.