HLA-A, HLA-B, HLA-C, HLA-DR, HLA-DQ TYPING IN A POPULATION GROUP OF SENEGAL, DISTRIBUTION OF HLA ANTIGENS AND HLA-DRB1-ASTERISK-13 AND DRB1-ASTERISK-11 SUBTYPING BY PCR USING SEQUENCE-SPECIFIC PRIMERS (PCR-SSP)

One-hundred-and sixteen Senegalese Serere were typed for HLA antigens and compared with other ethnic groups in Gambia. We did not find signi ficant differences (Fisher's exact test; P<0.01) in the HLA antigens d istribution between the Serere and Mandinka groups in Senegal and the Serere, Mandinka and Wolof in The Gambia. The most common HLA haplotyp es found (P<0.01; Chi square with Yates' correction) were: A1, B8; A2, B51; A32, B44; A33, B58; A2, Cw2; A2, Cw4; A33, Cw3; A2, DR17; A10, D R10; B35, Cw4; B53, Cw6; B57, Cw3; B65, Cw8; B50, DR15; B52, DR4; Cw2, DR17; DR7, DQ2; DR18, DQ4. The HLA-DRB 113 and DRB 1*11 alleles were subtyped by PCR-SSP and the frequencies of these alleles in the studi ed population given. HLA-DRB 11304 and DRB 1102 were the most common alleles found respectively 15.0 and 18.5%.