J. Bak et al., PARAGANGLIOMA OF THE CAUDA-EQUINA - A CASE-REPORT AND REVIEW OF THE LITERATURE, APMIS. Acta pathologica, microbiologica et immunologica Scandinavica, 104(3), 1996, pp. 234-240
A 59-year-old man presented with clinical evidence of a primary tumor
of the cauda equina region. It was well circumscribed and was complete
ly removed by neurosurgery. Routine staining showed that it had struct
ural similarities to an ependymoma, but immunohistochemistry with anti
sera to synaptophysin, NSE, chromogranin-A and PGP 9.5 proved it to be
a neuroendocrine tumor, i.e. a paraganglioma. We propose the use of e
ndocrine markers in cases with tumors of the cauda equina to different
iate a paraganglioma from an ependymoma. Paragangliomas appear to have
a better clinical outcome than ependymomas. Recurrence after surgery
for a paraganglioma in the cauda equina region, especially if it is en
capsulated, is rarely encountered.