HLA ANTIGENS AND ASTHMA IN GREEKS

HLA-A and -B antigens were determined in a group of 76 Creek asthmatic patients: 35 children (1.5-15 years) and 41 adults (18-73 years). The results were compared to those of 400 healthy unrelated controls from the same population. The standard NIH lymphocytotoxicity lest was app lied. When all 76 patients were compared to the controls, a statistica lly significant lower frequency of HLA-B5 and -B35 antigens was noted. When adults were analysed alone, an increased frequency of HLA-B8 was found. On the other hand, in the asthmatic children sub-group, the HL A-A10 antigen was significantly higher and the HLA-BS was significantl y lower than in the controls. These data imply that different HLA anti gens may be involved in the pathogenesis of several clinical forms of asthma and that, in order to study the role of immunogenetic factor(s) in the pathogenesis of this disease, more adequate grouping criteria are needed.