Gj. Vandam et al., ANTIBODY-RESPONSE PATTERNS AGAINST SCHISTOSOMA-MANSONI IN A RECENTLY EXPOSED COMMUNITY IN SENEGAL, The Journal of infectious diseases, 173(5), 1996, pp. 1232-1241
Acquired immune resistance is believed to be largely responsible for a
ge-dependent infection and reinfection patterns in schistosomiasis, In
a recently established but intense focus of Schistosoma mansoni in Se
negal, the humoral immune response was studied in a random population
sample of 289, Antibody levels of various isotypes to schistosome worm
and egg antigens were determined by ELISA and related to egg counts (
eggs per gram of feces [EPG]), age, and sex, Both IgG1 and IgG4 follow
ed age-related patterns similar to egg counts and strongly correlated
with EPG, even after allowing for age, Specific IgE levels increased s
lowly with age, The humoral immune response patterns in this recently
infected population appeared to be largely similar to those in chronic
ally infected communities, Thus far, the observations do not support t
he current hypothesis that age-related resistance to Schistosoma is de
termined by IgE-mediated protective immunity acquired during many year
s of exposure.