REDUCTION OF ADRIAMYCIN CARDIOTOXICITY BY ENOXIMONE

Citation
R. Bossa et al., REDUCTION OF ADRIAMYCIN CARDIOTOXICITY BY ENOXIMONE, Anticancer research, 16(1), 1996, pp. 141-143
Citations number
10
Categorie Soggetti
Oncology
Journal title
ISSN journal
02507005
Volume
16
Issue
1
Year of publication
1996
Pages
141 - 143
Database
ISI
SICI code
0250-7005(1996)16:1<141:ROACBE>2.0.ZU;2-A
Abstract
Several non catecholamine, non glycoside cardiotonic drugs have been d escribed recently. New compounds include amrinone, sulmazole, milrinon e and pimobendan. In an attempt to alleviate or prevent anthracycline toxicity, we have reported that these compounds reduce the negative ef fects of adriamycin, 4-epiadriamycin and esorubicin in isolated guinea pig atria. The present study reports the effects of a new cardiotonic agent:enoximone. Enoximone was administered after adriamycin (100 mu g/ml) on the isolated and spontaneously beating atria, and on electric ally driven left atria of guinea pig-in normodynamic and hypodynamic c onditions. Exposure for 60 minutes to the antitumor drug causes a depr ession of contractile force (g) and its derivative versus time (dF/dt, as maximal rate of contractile force). The negative effects of adriam ycin are antagonised by enoximone (100, 200 mu g/ml).