G. Griffon et al., SENSITIVITY TO TAXOID DERIVATIVES OF A NEWLY ESTABLISHED HUMAN ENDOMETRIOID OVARIAN ADENOCARCINOMA RADIORESISTANT CELL-LINE, Anticancer research, 16(1), 1996, pp. 177-187
An endometrioid ovarian adenocarcinoma cell line CAVEOC-2 was characte
rized. Maintained in monolayered culture, CAVEOC-2 cells exhibited a 3
3-hr doubling time. When xenografted into nude mice, these cells produ
ced fast growing tumors. Colony-forming efficiency in agar was 50%. DN
A index was 1.5 and cytogenetic analysis showed a triploid karyotype.
CAVEOC-2 cells did not express mdr-1 gene and were chemosensitive to d
oxorubicin (IC50 = 1.82+/-0.76 mu mol/l), paclitaxel (IC50 = 3.33+/-0.
26 nmol/l) and docetaxel (IC50 = 0.68+/-0.28 nmol/l), while they showe
d an intermediate sensitivity to cisplatin (IC50 = 9.40+/-1.02 mu mol/
l). CAVEOC-2 cells seemed highly radioresistant (SF2 = 0.81, alpha = 0
.02 Gy(-1), beta = 0.025 Gy(-2), and MID = 4.31 Gy). Activities of glu
tathione S transferase and gamma-glytamyl transpeptidase were respecti
vely 23.5- and 3.4- fold higher than those of sensitive A2780 cell lin
e. These characteristics make the CAVEOC-2 cells a suitable model for
the study of human endometrioid ovarian adenocarcinoma.