ANTITUMOR EFFECT OF CARBOPLATIN COMBINED WITH HYPERTHERMIA ON EHRLICH-ASCITES TUMOR IN-VIVO

We examined the optimal timing for the enhancement of antitumor effect s of CCDP analogues, cis- diammine-1,1-cyclobutane dicarboxylate plati num (II); CBDCA combined with hyperthermia against the CD-1 mice beari ng Ehrlich ascites tumor (EAT) cells in vivo. The prolonged tumor doub ling time was observed when two modalities were combined. The longest tumor doubling time was obtained by simultaneous administration of CBD CA combined with hyperthermia. The findings indicated that the most ef fective condition was the simultaneous combination of CBDCA with hyper thermia. An increase in intratumoral platinum concentration was observ ed by the treatment of CBDCA simultaneous combined with hyperthermia.