CARBOPLATIN-BASED CHEMOTHERAPY IN PATIENTS UNDERGOING HEMODIALYSIS

In the present study, we investigated the pharmacology of carboplatin in two patients with chronic renal failure undergoing hemodialysis. In Case 1, squamous cell carcinoma of the epipharynx was treated with 26 5 mg/m2 of carboplatin alone. In Case 2, adenocarcinoma of the lung wa s treated with 300 mg/m(2) of carboplatin in combination with 50 mg/m( 2) of etoposide. All agents were injected intravenously. Hemodialysis was initiated 30 minutes after carboplatin administration. Most platin um was excluded by hemodialysis in a pattern similar to that in patien ts with normal renal function. These observations suggest that carbopl atin-based chemotherapy can be considered as a treatment modality for malignant neoplasia in patients with chronic renal failure undergoing hemodialysis.