We show that the giant magnetoresistance in sputtered Ni-Fe/Cu/Ni-Fe/F
e-Mn spin-valve structures is strongly reduced by the presence of comp
ositionally intermixed regions at the NiFe/Cu interfaces. The ultrathi
n intermixed layers, which are not ferromagnetic, are centers of stron
g spin-independent scattering, thus reducing the flow of polarized ele
ctrons from one ferromagnetic layer to the other. Our results show tha
t interfacial spin-independent scattering must be included in the theo
ry of giant magnetoresistance.