AGE-RELATED-CHANGES OF IGA IMMUNOCYTES AND SERUM AND SALIVARY IGA AFTER TONSILLECTOMY

For determining treatment options of tonsillar diseases, the authors c ompared immunohistochemical differences for IgA immunocytes and measur ed the changes in concentrations of the serum immunoglobulin A and sal ivary secretory immunoglobulin A before and after tonsillectomy accord ing to age in 126 cases (60 control cases, 66 tonsillectomee cases). T he serum IgA and salivary SIgA concentrations of the control group rea ched to adult's level at the age of 11 to 13. In the tonsillectomees, the serum IgA concentrations below the age of 10 were higher than that of controls and were decreased to the levels of the controls after to nsillectomy in all ages and the salivary SIgA concentrations were decr eased to the levels of the controls at the 30th postoperative day, esp ecially at the age of 5 to 7 and 8 to 10. Morphometric features of ton sils in the group below the age of 8 were more active than those in th e group above the age of 8 in the controls. In the tonsillectomees, mo rphometric features of the tonsils were similar to those in the group above the age of 8, but the reticular part of the crypt epithelium rem ained significantly. Total number of IgA immunocytes was the highest a t the age of 5 to 7 with a decline by age, especially at the age of 19 in the controls. In the tonsillectomee group, the number of IgA immun ocytes of the extrafollicular area and the reticular part of crypt epi thelium decreased below the levels of the control group. In conclusion , tonsils in preschool children are important as a local immunologic d efense mechanism, but no significant changes in the immunologic system occurs after tonsillectomy.