DIABETIC NEUROPATHY AND DOPAMINE-BETA-HYDROXYLASE

A 62-year-old mole Presented with a year's history of progressive diff iculty with walking. He had a previous history of alcohol abuse but ha d not taken alcohol for at least three years. He had, however, taken d isulfiram intermittently over twenty years. He was found to have diabe tes mellitus. Following treatment of his diabetes with a diabetic diet and sulphonylurea, and cessation of disulfiram, his gait improved. We speculate that this man's neuropathy could have resulted from the dia betes and disulfiram with the common link being depression of beta-hyd roxylose.