Pb. Laub et Jm. Gallo, NCOMP - A WINDOWS-BASED COMPUTER-PROGRAM FOR NONCOMPARTMENTAL ANALYSIS OF PHARMACOKINETIC DATA, Journal of pharmaceutical sciences, 85(4), 1996, pp. 393-395
The computer program NCOMP performs noncompartmental analysis of pharm
acokinetic data obtained from iv bolus, continuous infusion, and oral
modes of administration. Integration of area-under-the-curve and area-
under-the-first-moment-curve is done by either Lagrange polynomials or
the hybrid method of Purves, which uses parabola-through-the-origin a
nd log trapezoidal algorithms. Written for Microsoft Windows, NCOMP is
designed to be used in conjunction with a spreadsheet program for gra
phical display and handling of data. NCOMP interactively aids the user
in determining how best to extrapolate the areas to time infinity and
in estimating the time zero concentration for iv bolus data.