ACUTE AND SUBCHRONIC ORAL TOXICITY OF TECHNICAL QUINALPHOS IN RATS

Authors
RAIZADA RB SRIVASTAVA MK SINGH RP KAUSHAL RA GUPTA KP DIKSHITH TSS
Citation
Rb. Raizada et al., ACUTE AND SUBCHRONIC ORAL TOXICITY OF TECHNICAL QUINALPHOS IN RATS, Veterinary and human toxicology, 35(3), 1993, pp. 223-225
Citations number
17
Categorie Soggetti
Toxicology,"Veterinary Sciences
Journal title
Veterinary and human toxicology → ACNP
ISSN journal
01456296
Volume
35
Issue
3
Year of publication
1993
Pages
223 - 225
Database
ISI
SICI code
0145-6296(1993)35:3<223:AASOTO>2.0.ZU;2-8
Abstract
The organophosphate insecticide quinalphos is extensively used in agri culture. on the mammalian toxicity of quinalphos is limited. The acute po LD50 of technical quinalpos was 19.95 mg/kg in males and 13.78 mg/ kg in female rats. Administration of 0.75, 1.50 or 3.9 mg/kg/d technic al quinalphos for 90 d po to rats produced poisoning and death. Male r ats were more susceptible to quinalphos than female rats in the subchr onic toxicity studies based on mortality, enzyme profiles and cholines terase inhibition.