FURTHER MODEL STUDIES RELATED TO FREDERICAMYCIN-A - ANALOGS IN WHICH RING-C IS EXPANDED TO 6 ATOMS, AND AN EXAMINATION OF THE DIASTEREOSELECTIVITY OF RADICAL SPIROCYCLIZATION

Authors
CLIVE DLJ KONG XL PAUL CC
Citation
Dlj. Clive et al., FURTHER MODEL STUDIES RELATED TO FREDERICAMYCIN-A - ANALOGS IN WHICH RING-C IS EXPANDED TO 6 ATOMS, AND AN EXAMINATION OF THE DIASTEREOSELECTIVITY OF RADICAL SPIROCYCLIZATION, Tetrahedron, 52(17), 1996, pp. 6085-6116
Citations number
17
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
52
Issue
17
Year of publication
1996
Pages
6085 - 6116
Database
ISI
SICI code
0040-4020(1996)52:17<6085:FMSRTF>2.0.ZU;2-6
Abstract
The fredericamycin A analogues 5 and 23 were synthesized. A key step i s the process of radical spirocyclization, and the diastereoselectivit y of this reaction was studied with model compounds. In vitro tests sh owed that 23 was active against certain cell lines of colon and prosta te cancer, while compound 5 was essentially inactive. (C) 1996 Elsevie r Science Ltd.