DESTRUXIN ANALOGS - DEPSI PEPTIDIC BOND REPLACEMENT BY AMIDE BOND

Authors
CAVELIER F JACQUIER R MERCADIER JL VERDUCCI J
Citation
F. Cavelier et al., DESTRUXIN ANALOGS - DEPSI PEPTIDIC BOND REPLACEMENT BY AMIDE BOND, Tetrahedron, 52(17), 1996, pp. 6173-6186
Citations number
28
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
52
Issue
17
Year of publication
1996
Pages
6173 - 6186
Database
ISI
SICI code
0040-4020(1996)52:17<6173:DA-DPB>2.0.ZU;2-O
Abstract
In order to determine the importance of the depsi bond present in natu ral destruxins, we have investigated the replacement of this ester bon d by an amide bond, leading to a new family of analogues. Synthesis of six specific members of this new class of compounds is reported. Sinc e none of these cyclopeptides showed any biological activity, we undou btedly proved that the depside group is a requisite for insecticide ef fect. (C) 1996 Elsevier Science Ltd.