CYCLOLEONURIPEPTIDE-A, CYCLOLEONURIPEPTIDE-B AND CYCLOLEONURIPEPTIDE-C, 3 NEW PROLINE-RICH CYCLIC NONAPEPTIDES FROM LEONURUS-HETEROPHYLLUS

Authors
MORITA H GONDA A TAKEYA K ITOKAWA H
Citation
H. Morita et al., CYCLOLEONURIPEPTIDE-A, CYCLOLEONURIPEPTIDE-B AND CYCLOLEONURIPEPTIDE-C, 3 NEW PROLINE-RICH CYCLIC NONAPEPTIDES FROM LEONURUS-HETEROPHYLLUS, Bioorganic & medicinal chemistry letters, 6(7), 1996, pp. 767-770
Citations number
10
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
7
Year of publication
1996
Pages
767 - 770
Database
ISI
SICI code
0960-894X(1996)6:7<767:CCAC>2.0.ZU;2-E
Abstract
Three new proline-rich cyclic nonapeptides, cycloleonuripeptides A: cy cle (-Gly-Pro-Pro-Pro-Tyr-Pro-Pro -Met-Ile-), B: cycle (-Gly-Pro-Pro-P ro-Tyr-Pro-Pro-Met(O)-Ile-), and C: cycle (-Gly-Pro-Pro-Pro-Tyr-Pro-Pr o-Met(O)-Ile), have been isolated from the fruits of Leonurus heteroph yllus and their structures were elucidated by extensive 20 NMR methods , chemical degradation and transformation. Cycloleonuripeptides B and C, both of which are epimer, showed cell growth inhibitory activity. C opyright (C) 1996 Elsevier Science Ltd