SYNTHESIS AND IN-VITRO CYTOTOXICITY OF R)-4,5-BIS(AMINOMETHYL)-1,3-DIOXOLANE]PLATINUM(II)

Authors
KIM DK GAM JS KIM HT KIM KH
Citation
Dk. Kim et al., SYNTHESIS AND IN-VITRO CYTOTOXICITY OF R)-4,5-BIS(AMINOMETHYL)-1,3-DIOXOLANE]PLATINUM(II), Bioorganic & medicinal chemistry letters, 6(7), 1996, pp. 771-774
Citations number
29
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
7
Year of publication
1996
Pages
771 - 774
Database
ISI
SICI code
0960-894X(1996)6:7<771:SAICOR>2.0.ZU;2-5
Abstract
The synthesis and in vitro cyto toxicity of R)-4,5-bis(aminomethyl)-1, 3-dioxolane]platinum(II) are described. Among them, cis-(glycolato-O,O ') [(4R,5R)-4,5-bis (aminomethyl)-2,2-diethyl-1,3-dioxolane] platinum( II) (26) was found to be almost equally cytotoxic to cisplatin against two human non-small cell lung cancer cell lines, PC-9 and PC-14, and two human stomach cancer cell lines, MKN-45 and KATO III. Copyright (C ) 1996 Elsevier Science Ltd