ONE-STEP SYNTHESIS OF RADIOIODINATED BIOTIN DERIVATIVES

Authors
FOULON CF ADELSTEIN SJ KASSIS AI
Citation
Cf. Foulon et al., ONE-STEP SYNTHESIS OF RADIOIODINATED BIOTIN DERIVATIVES, Bioorganic & medicinal chemistry letters, 6(7), 1996, pp. 779-784
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
7
Year of publication
1996
Pages
779 - 784
Database
ISI
SICI code
0960-894X(1996)6:7<779:OSORBD>2.0.ZU;2-P
Abstract
A direct method of radioiodination of biotin derivatives is presented whereby radiolabeled sodium iodide is exchanged with a tributylstannyl group under oxidative conditions. The in vitro binding of each radioi odinated biotin derivative to streptavidin is saturable acid three of the compounds exhibit a strong affinity for streptavidin. All the biot in-streptavidin complexes are rapidly catabolized in human serum. Copy right (C) 1996 Elsevier Science Ltd